Molecular characterization of ferroptosis in soft tissue sarcoma constructs a prognostic and immunotherapeutic signature through experimental and bioinformatics analyses

Zhi-Qiang Yang; Liang-Yu Guo; Kang-Wen Xiao; Chong Zhang; Min-Hao Wu; Fei-Fei Yan; Lin Cai

doi:doi:10.18632/aging.205133

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Research Paper Volume 15, Issue 20 pp 11412—11447

Molecular characterization of ferroptosis in soft tissue sarcoma constructs a prognostic and immunotherapeutic signature through experimental and bioinformatics analyses

Figure 5. Identification of two ferroptosis modification patterns in STS. (A) The result of consensus clustering analysis in STS. (B) Heatmap of expression of 16 ferroptosis regulators in Fe clusters A and B. (C) The result of PCA of two Fe clusters. (D) Survival plot of two clusters in TCGA-SARC (p = 0.0018). (E) Enriched pathways in Fe cluster A: α interferon response. (F) Enriched pathways in Fe cluster A: γ interferon response. (G) Enriched pathways in Fe cluster A: p53 pathway. (H) Enriched pathways in Fe cluster B: WNT signaling. (I) Enriched pathways in Fe cluster B: angiogenesis.