Research Paper Volume 15, Issue 20 pp 11298—11312

Single-cell landscape and spatial transcriptomic analysis reveals macrophage infiltration and glycolytic metabolism in kidney renal clear cell carcinoma

class="figure-viewer-img"

Figure 3. Resolving spatial relationships of cell type and gene expression using spatial transcriptomics in a mouse kidney injury model. (A) H&E-stained sections of 3 mouse models: sham operation, ischemia/reperfusion injury (IRI), and cecal ligation and puncture (CLP), respectively. Different regions of the cortex (Lrp2) and medulla (Aqp2) were labeled using tissue-specific biomarkers. (B) Analysis of Pgam1 and different biomarkers of renal injury (Lcn2, Kim1, Havcr1).