Electroacupuncture pretreatment protects against anesthesia/surgery-induced cognitive decline by activating CREB via the ERK/MAPK pathway in the hippocampal CA1 region in aged rats

Hongjie Huang; Yanan Li; Xupeng Wang; Qi Zhang; Juan Zhao; Qiujun Wang

doi:doi:10.18632/aging.205124

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Research Paper Volume 15, Issue 20 pp 11227—11243

Electroacupuncture pretreatment protects against anesthesia/surgery-induced cognitive decline by activating CREB via the ERK/MAPK pathway in the hippocampal CA1 region in aged rats

Figure 8. Schematic diagram of the neuroprotective effect of EA pretreatment (drawn by Figdraw, ID: IWWRSae558). EA pretreatment improves synaptic plasticity by activating CREB via the ERK/MAPK pathway in the hippocampal CA1 region, thereby inhibiting cognitive decline caused by surgery and anesthesia in aged rats.