Research Paper Volume 15, Issue 20 pp 11092—11113

Identification and validation of a cancer-associated fibroblasts-related scoring system to predict prognosis and immune landscape in hepatocellular carcinoma through integrated analysis of single-cell and bulk RNA-sequencing

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Figure 12. TIME analysis based on the CAFRss. (A) Bubble plots display the correlation between risk scores and different immune cells in the TIMER 2.0 platform. (B) ssGSEA shows differences in immune function score across the subgroups. (C) ssGSEA shows differences in immune cells score across the risk groups. (DF) Box plots display the differences in immune, stromal and ESTIMATE scores across the two subgroups. (G) Box plots show the differences in expression of immune checkpoints across the risk subgroups. *P < 0.05, **P < 0.01, and ***P < 0.001.