Research Paper Volume 15, Issue 20 pp 11033—11051

Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis

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Figure 6. Graphical abstract showing that the oncogenic activity of SSH1 is mediated by circadian rhythm disruption and Wnt/β-catenin signaling activation, and that SHH1 is molecular and pharmacological target in patients with HCC.