Research Paper Volume 15, Issue 16 pp 8458—8470
Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia
Figure 5. The role of curcumin on the decrease of dendritic spine density induced by pT-ION in the mice hippocampal CA1 region. (A) The representative Golgi-Cox-staining images showing the density and morphology of dendritic spines in the cone cell layer of hippocampal CA1 region in each group (scale bar: 5 μm). (B) The analysis of total dendritic spine density in each group. (C) The analysis of mushroom-type dendritic spine density in each group. N = 8 mice/group. *P < 0.05 and ***P < 0.001 vs. sham group; ###P < 0.001 vs. pT-ION group, one-way ANOVA and Tukey’s test.