Research Paper Volume 15, Issue 16 pp 8444—8457
m6A methyltransferase METTL16 mediates immune evasion of colorectal cancer cells via epigenetically regulating PD-L1 expression
Figure 6. METTL16 modulates CRC cell growth in vivo. The xenograft mouse model was established using control and METTL16 overexpressed SW480 cells and treated with anti-PD-1 antibody. (A) Images of tumors were taken. (B) Tumor growth curve was recorded. (C) The expression of Ki-67 was measured by IHC assay. (D) The expression of CD8 and CD4 in tumor tissues was measured by IHC assay. **p<0.01.