Research Paper Volume 15, Issue 16 pp 8298—8314
Gastrodin ameliorates cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation
Figure 7. Diagram illustrating the effects of diabetes on hippocampal neurons. Diabetes could enhance the phosphorylation of PAK2, which reduces the expression of PI3K and thus the phosphorylation of AKT. It leads to decreased expression of GLUT4, which is important for glucose uptake.