Research Paper Volume 15, Issue 16 pp 8298—8314
Gastrodin ameliorates cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation
Figure 1. Gastrodin intervention ameliorated diabetes-induced cognitive dysfunction and pathological changes in the CA1 area of the hippocampus. Escape latency (A) number of platform entries (B) and time spent in target quadrant (C) of rats from the NC9w, DM9w+S, DM9w+G60 and DM9w+G120 groups in the probe trial. (D–G) H&E staining of CA1 area of hippocampus in the NC9w, DM9w+S, DM9w+G60 and DM9w+G120 groups. Black arrows indicated the nucleus of the damaged neuron and arrowheads indicated the synapse. Bar = 50 μm. *p < 0.05, **p < 0.01.