Unlocking the potential of senescence-related gene signature as a diagnostic and prognostic biomarker in sepsis: insights from meta-analyses, single-cell RNA sequencing, and <i>in vitro</i> experiments

Jia Chen; Jinhong Si; Qiankun Li; Weihong Zhang; Jiahao He

doi:doi:10.18632/aging.205574

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Research Paper Volume 16, Issue 4 pp 3989—4013

Unlocking the potential of senescence-related gene signature as a diagnostic and prognostic biomarker in sepsis: insights from meta-analyses, single-cell RNA sequencing, and in vitro experiments

Figure 6. Association between SRS and clinical features in sepsis. (A) SRS was associated with ICU infection condition in the training cohort. (B) SRS was linked with age in the GSE95233 cohort. (C, D) SRS was an independent predictor of prognosis in both univariate (C) and multivariate (D) Cox analyses in the training cohort. (E, F) SRS was an independent predictor of prognosis in both univariate (E) and multivariate (F) Cox analyses in the GSE95233 cohort. *P < 0.05, **P < 0.01.