Research Paper Volume 16, Issue 4 pp 3989—4013

Unlocking the potential of senescence-related gene signature as a diagnostic and prognostic biomarker in sepsis: insights from meta-analyses, single-cell RNA sequencing, and in vitro experiments

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Figure 5. SRS was a reliable predictor of prognosis in sepsis. (A) Cases in the training, GSE95233, and GSE4607 cohorts were divided into high- and low-SRS subgroups based on the same cut-off value. (BD) Kaplan-Meier survival analyses indicated the prognostic value of SRS for sepsis in the training (B), GSE4607 (C), and GSE95233 (D) cohorts. (EG) SRS was associated with survival status in the training (E), GSE4607 (F), and GSE95233 (G) cohorts. (H, I) Meta-analyses were conducted to combine effect values using continuous SRS (H) and binary SRS (I). Abbreviations: SRS, senescence-related score.