MicroRNA-320a enhances LRWD1 expression through the AGO2/FXR1-dependent pathway to affect cell behaviors and the oxidative stress response in human testicular embryonic carcinoma cells

Yi-Hsiung Lin; Chia-Hui Su; Hsin-Mei Chen; Ming-Syuan Wu; Hsien-An Pan; Chia-Ning Chang; Yu-Sheng Cheng; Wen-Tsan Chang; Chien-Chih Chiu; Yen-Ni Teng

doi:doi:10.18632/aging.205571

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Research Paper Volume 16, Issue 4 pp 3973—3988

MicroRNA-320a enhances LRWD1 expression through the AGO2/FXR1-dependent pathway to affect cell behaviors and the oxidative stress response in human testicular embryonic carcinoma cells

Figure 6. LRWD1 and miR-320a expression and their regulatory effect in response to oxidative stress. The gene expression of (A) miR-320a and (B) LRWD1 responding to the oxidative stress OH^- (H₂O₂), NO donor (SNP), and the individual inhibitor treatments. (C) The activity of LRWD1 stimulated by miR-320 mimic and SNP in NT2D1 cells (^***p < 0.001 compared with the vector-only control; ^###p < 0.001 and ^&&&p < 0.001 compared with the indicated groups).