Research Paper Volume 16, Issue 4 pp 3934—3954
Functional enrichment analysis reveals the involvement of DARS2 in multiple biological pathways and its potential as a therapeutic target in esophageal carcinoma
Figure 3. Functional enrichment analysis of DARS2 in ESCA. (A) The volcano plot exhibits the genes significantly correlated with DARS2 expression in the TCGA ESCA dataset. (B, C) Heatmap was used to visually display the top 10 most significant genes positively and negatively correlated with DARS2 expression. (D) Enrichment analysis was performed on co-expression genes of DARS2 using Gene Ontology (GO) terms and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. (E) GSEA analysis revealed DARS2 related pathways. *p < 0.05; **p < 0.01; ***p < 0.001; ns, no significance.