Netrin-1 mitigates acute lung injury by preventing the activation of the Toll-like receptor 4/nuclear factor-κB (TLR4/NF-κB) signaling

Jian Su; Zhu Jian; Miao Zou; Huasheng Tong; Peng Wan

doi:doi:10.18632/aging.205527

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Research Paper Volume 16, Issue 3 pp 2978—2988

Netrin-1 mitigates acute lung injury by preventing the activation of the Toll-like receptor 4/nuclear factor-κB (TLR4/NF-κB) signaling

Figure 4. Netrin-1 inhibited the expression of pro-inflammatory cytokines and chemokines in lung tissues in LPS-challenged ALI mice. (A) mRNA of IL-8; (B) mRNA of IL-1β; (C) mRNA of CXCL2; (D) Protein of IL-8; (E) Protein of IL-1β; (F) Protein of CXCL2 (^††P < 0.01 vs. vehicle group; ^**P < 0.01 vs. LPS group).