Research Paper Volume 16, Issue 3 pp 2789—2811
Targeting PERK-ATF4-P21 axis enhances the sensitivity of osteosarcoma HOS cells to Mppα-PDT
Figure 9. The potential mechanisms of inhibiting Perk-ATF4-P21 pathway to enhance the efficacy of MPPα-PDT. Antitumor ability of Mppα-PDT is improved by inhibiting PERK signaling, which is achieved by P21 regulating autophagy.