Research Paper Volume 16, Issue 3 pp 2753—2773

Figure 2. Correlations of DRG clusters with CRSGs, ICGs, and TME. (A) The TCGA-LUAD cohort was partitioned into two distinct clusters based on the consensus clustering matrix (k = 2). (B) Uniform clustering CDF with k from 2 to 9. (C) The alteration in the area beneath the CDF curve as the value of k varies from 2 to 9. (D) The PCA plot showed the distribution of samples among 2 DRG clusters. (E) Kaplan-Meier survival analysis for two DRG clusters. (F) The heatmap analysis revealed distinct patterns of ICGs expression, as well as clinicopathological features, that distinguished DRG cluster 1 from DRG cluster 2. (G) The differential expression of seven CRSGs between two distinct clusters of DRGs. (H) Exploring the correlations between CRG clusters and TME scores. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001.