Research Paper Volume 16, Issue 3 pp 2657—2678

Figure 2. Differential expression of AAGs in MM and generation of angiogenesis subgroups. (A) Differences in the expression of AAGs between MM patients and healthy controls (^*P < 0.05; ^**P < 0.01; ^***P < 0.001; ^****P < 0.0001). (B) Representative images of MM patient BM tissues stained with CD34 and VEGFA antibodies (scale bar, 50 μm). Overall survival analyses of the MVD group (C) and VEGFA group (D) using Kaplan–Meier curves. (E) Consensus matrix heatmap depicting three gene clusters associated with the AAGs. The colors indicate the similarity or dissimilarity among samples at each iteration, with blue indicating higher similarity and white indicating lower similarity. (F) PCA based on the AAGs revealed three disjointed populations. Red, cluster A samples; green, cluster B samples; blue, cluster C samples. (G) OS analysis of patients in the AAG_clusters using Kaplan–Meier curves.