Research Paper Volume 16, Issue 3 pp 1983—2004
GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model through anti-aging effects
Figure 4. Effect of GV1001 on neurodegeneration. Markers of neurodegeneration were studied in aged 3xTg-AD mice treated with GV1001 and saline. (A) Neurodegeneration was evaluated by the volume of the CA1, CA3 and dentate gyrus (DG) in the hippocampus and (B, C) expression of neuronal markers, such as neuronal nuclei (NeuN) and neuron-specific β III tubulin (Tuj1) of the CA1 in the hippocampus. GV1001 markedly prevented neuronal loss in the hippocampus of 3xTg-AD mice. *P < 0.05; **P < 0.01 (vs. the control group). Scale bar = 30 μm (a) and 100 μm (b).