Research Paper Volume 16, Issue 3 pp 2249—2272
Identification of gut microbes-related molecular subtypes and their biomarkers in colorectal cancer
Figure 6. Creation of a risk profile through stepwise multiple Cox regression analysis based on two GMRGs. (A) Analysis of GMRG risk scores: distribution of risk scores among CRC patients; survival status and duration of CRC patients; heatmap illustrating the expression of 2 genes. (B) K-M survival analysis of CRC patients in the high and low-risk groups in the TCGA-COAD cohort. (C) ROC calibration curves predicting overall survival at 5, 10, and 30 months in the high- and low-risk groups. (D) Sankey diagram illustrating the differential distribution of CRC patients in CRC consensus molecular subtypes, GM subtypes, survival outcomes, and high- and low-risk groups. Abbreviations: GMRGs: gut microbes-related genes; CRC: colorectal cancer; K-M: Kaplan-Meier; ROC: receiver operating characteristic; GM: gut microbes.