Research Paper Volume 16, Issue 3 pp 2232—2248

Identification of an immune-related eRNA prognostic signature for clear cell renal cell carcinoma

class="figure-viewer-img"

Figure 3. Establishment prognostic analysis of immune-related eRNAs signature. (A) LASSO coefficient profiles of the expression of prognostic immune-related eRNAs. (B) Selection of the penalty parameter (λ) in the LASSO model via 10-fold cross-validation. (C) Results of immune-related eRNAs multivariate analysis; (D) Relationship between the survival status/immune-related eRNAs signature rank and survival time (years)/immune-related eRNAs signature rank; (E) Distribution of immune-related eRNAs expression and clinical phenotype between high and low risk groups; (F) KM curve showing the survival differences between high and low risk groups; (G) Time-dependent ROC curve for OS of the riskscore. The AUC was assessed at 1, 2 and 3 years; The univariate (H) and multivariate (I) Cox regression analysis of riskscore, age, gender, grade, stage, and TMN.