Research Paper Volume 16, Issue 3 pp 2181—2193

(-)-Epicatechin protects against myocardial ischemia/reperfusion injury via autophagy-dependent ferroptosis

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Figure 2. EPI increases antioxidant properties in cardiac tissues. (A) The activity of SOD in cardiac tissues. (B) The content of MDA in cardiac tissues. (C) The concentration of Fe2+ in cardiac tissues. (D) The content of ROS in cardiac tissues. (E) The fluorescent intensity of LC3 and NCOA4 in myocardial tissues. I/R + L-EPI: 1 mg/kg/day of EPI; I/R + H-EPI: 2 mg/kg/day of EPI. Data (n=6) are expressed as mean ± SD, *P < 0.05 compared with I/R group, **P < 0.01 compared with I/R group.