Research Paper Volume 16, Issue 3 pp 2181—2193

(-)-Epicatechin protects against myocardial ischemia/reperfusion injury via autophagy-dependent ferroptosis

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Figure 1. EPI alleviates myocardial ischemia-reperfusion injury in vivo. (A) Electrocardiogram of each group of rats after modeling. (B) TTC staining of cardiac tissues in each group. (C) Infarction rates of cardiac tissues in each group. (D) Effects of EPI on histopathological changes of cardiac tissues suffered from surgical procedures of ischemia-reperfusion, and histogram scores of myocardial tissue of rats in each group. I/R + L-EPI: 1 mg/kg/day of EPI; I/R + H-EPI: 2 mg/kg/day of EPI. Data (n=6) are expressed as mean ± SD, *P < 0.05 compared with I/R group, **P < 0.01 compared with I/R group.