Research Paper Volume 16, Issue 3 pp 2161—2180

Figure 1. The expression levels and prognostic values of LAG3 in KIRC. (A) LAG3 mRNA expression level in diverse tumors and their adjacent normal tissues from TCGA. (B) Correlation between LAG3 expression and clinical stage in pan-cancer. (C) Correlation between LAG3 expression and clinical grade in pan-cancer. Blue bars represent higher level expression and are associated with later stage, and grade. (D) Comparison of LAG3 expression between KIRC cancer tissues and normal or matched normal tissues. (E) The trend of high and low expression of LAG3 for different clinical characteristics and survival status. LAG3 expression in different clinical and pathological features of KIRC, including pathologic stages, histologic grades (F), pathologic N stage, pathologic M stage (G), and OS event (H). (I) Kaplan–Meier curves of OS between high and low LAG3 expression groups. (J) Univariate Cox regression analysis of LAG3. (K) ROC curve to evaluate the diagnostic value of LAG3 expression in distinguishing KIRC tumor tissue from normal tissue. (L) Nomogram to predict the 1-year, 3-year, and 5-year OS of KIRC. (M) Nomogram calibration curve for the OS. Abbreviation: OS: overall survival. (^*P < 0.05; ^**P < 0.01; ^***P < 0.001).