Research Paper Volume 16, Issue 2 pp 1911—1924

Investigation of Tongxie-Yaofang formula in treating ulcerative colitis based on network pharmacology via regulating MAPK/AKT signaling pathway

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Figure 5. The protective effect of TXYF on UC rat model. (A) The colon in UC model group (MOD) and UC model+ TXYF group (MOD+T) at 14th day after the UC model was established. (B) The activity of Myeloperoxidase (MPO) in MOD and MOD+T groups was measured at 3rd, 7th, and 14th day after the UC model was established. (C) The representative images of hematoxylin-eosin (H&E) staining of colon collected from MOD and MOD+T groups at 3rd, 7th, and 14th day after the UC model was established. (D) The concentration of HIF-1, IL-17 and TNF-α in MOD and MOD+T groups was measured at 3rd, 7th, and 14th day after the UC model was established. N=5, *p<0.05, **p<0.01, and ***p<0.001.