Research Paper Volume 16, Issue 2 pp 1620—1639
PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance
Figure 8. Overall summary of our study. CAFs educated CRC cells under the modulation of the expression of PROXA1 results in induced invasive, tumor progression and resistance properties. Furthermore, the reversal of aforementioned properties was observed after the shRNA-PROXA1 mediated inhibition of PROXA1, resulting in resensitization of CRC tumor towards the therapy.