Research Paper Volume 16, Issue 2 pp 1555—1580

Figure 2. Manhattan plots for the PD PWASs in the human brain and plasma proteomes. Manhattan plot for the PWAS integrating the PD GWAS with the ROSMAP proteomes (n= 376) (A), Banner proteomes (n= 152) (B), plasma proteomes (n= 152) (C). Each dot on the x-axis represents a gene, and the association strength on the y-axis represents the -log₁₀(p) of PWAS. Proteome-wide significance level was set at p < 4.36×10^-5 (adjusted by Bonferroni multiple testing correction method) for the Banner dataset. Proteome-wide significance level in the ROSMAP dataset was set at p < 3.39×10^-5 (adjusted by Bonferroni multiple testing correction method). Proteome-wide significance level in the ROSMAP dataset was set at p < 3.71×10^-5 (adjusted by Bonferroni multiple testing correction method). Genes that were proteome-wide significant (CD38, GPNMB) in both brain proteomes are shown in red. Chr, chromosome.