Treadmill exercise can regulate the redox balance in the livers of APP/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis

Shunling Yuan; Yirong Wang; Jialun Yang; Yingzhe Tang; Weijia Wu; Xiangyuan Meng; Ye Jian; Yong Lei; Yang Liu; Changfa Tang; Zhe Zhao; Fei Zhao; Wenfeng Liu

doi:doi:10.18632/aging.205432

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Research Paper Volume 16, Issue 2 pp 1374—1389

Treadmill exercise can regulate the redox balance in the livers of APP/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis

Figure 3. Glutathione system and total antioxidant capacities of the animals’ livers. (A) Relative expressions of Gss mRNA. (B) Relative expressions of Gsr mRNA. (C) Relative expressions of Gclm mRNA. (D) Relative expressions of Gclc mRNA. (E) Contents of GSH in the animals’ livers. (F) Total antioxidant capacities of the animals’ livers (n = 6 in each group). The data are expressed as means ± SDs. # p < 0.05 compared with the WT group and * p < 0.05 compared with SE-AD group.