Research Paper Volume 16, Issue 1 pp 617—626

GDF15 restrains myocardial ischemia-reperfusion injury through inhibiting GPX4 mediated ferroptosis

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Figure 3. pc-DNA-GDF15 significantly inhibited the oxidative stress condition and inflammation response. (A, B) Detection of oxidative stress biomarkers including MDA, GSSG, GSH in the serum and myocardial tissues. (C) Measurement of the serum levels of IL-1β, TGF-β, and IL-6. *P < 0.05, **P < 0.01, ***P < 0.001.