Research Paper Volume 16, Issue 2 pp 1182—1191
Myeloid-specific knockout of Notch-1 inhibits MyD88- and TRIF-mediated TLR signaling pathways by regulating oxidative stress-SHP2 axis, thus restraining aneurysm progression
Figure 6. Monocytes/macrophages-specific knockout of Notch1 promotes phagocytic capacity by promoting the SHP2 signaling pathway. (A) Immunofluorescent spheroid phagocytosis experimental results; (B) Macrophage engulfs fluorescent spheroid count statistics. N = 3, **P < 0.01, WT group vs. KO group, WT+PHPS1 group vs. KO+PHPS1 group.