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Research Paper Volume 15, Issue 23 pp 14323—14332

Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation

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Figure 2. Notch-1MAC-KO regulates the expression of inflammation-related factors and lipid synthesis proteins in macrophages of HFD-induced NAFLD mice. (A) Protein band plots of SREBP1C, SREBP2, LXR, IL-1β, IL-18 and Notch-1 in macrophages. (B) Relative protein expression of SREBP1C, SREBP2, LXR, IL-1β, IL-18 and Notch-1 in macrophages. (**p < 0.01, *p < 0.05, ns: p > 0.05; N = 6).