Research Paper Volume 15, Issue 23 pp 13961—13979

Cathepsin V drives lung cancer progression by shaping the immunosuppressive environment and adhesion molecules cleavage

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Figure 1. Identification of CTSV as the driver for malignant progression of lung cancer. (A) CTSV expression analysis in pan-cancer using tumor tissues paired with normal tissues from the TCGA database. (B) CTSV expression analysis of lung cancer using lung cancer and normal samples from the TCGA database. (CE) Kaplan-Meier survival curves based on CTSV expression in the lung cancer samples. (F) ROC analysis of lung cancer based on CTSV expression. (G, H) The expression of CTSV was analyzed based on OS events and residual tumor. (IL) Relationship between CTSV expression and clinical outcomes including (I) Pathologic stage, (J) N stage, (K) T stage, (L) M stage. *P < 0.05, **P < 0.01, ***P < 0.001.