Research Paper Volume 15, Issue 23 pp 13920—13943

Figure 2. The screening of key genes in the melanoma pathway. (A) The volcano map shows differential genes between primary and metastatic melanoma. The red points represent up-regulated genes and the blue ones represent down-regulated genes in the metastatic samples. The top 10 up- and down-regulated genes with the highest significance were labeled. (B) The Venn diagram shows screening conditions for key genes. (C) The expression levels of 4 key genes in melanoma. (D) The expression levels of 4 key genes in normal and melanoma tissues. * p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001.