Effects of paternal and chronological age on <i>BEGAIN</i> methylation and its possible role in autism

Ramya Potabattula; Andreas Prell; Marcus Dittrich; Caroline Nava; Christel Depienne; Yosra Bejaoui; Nady El Hajj; Thomas Hahn; Martin Schorsch; Thomas Haaf

doi:doi:10.18632/aging.205275

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Research Paper Volume 15, Issue 22 pp 12763—12779

Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism

Figure 5. Hypomethylation of the BEGAIN promoter CpG 13521842 in autistic brain. Re-analysis of genome-wide Infinium 450K human methylation array data [20], using GEO2R tool in male brain samples. The box plots reveal hypomethylation (p = 0.059) in the anterior cingulate cortex of 8 male autistic individuals, compared to 10 controls.