Research Paper Volume 15, Issue 22 pp 12763—12779
Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism
Figure 4. Hypomethylation of the BEGAIN promoter in peripheral blood samples of autistic individuals. Box plots showing methylation (y-axis in %) of the human BEGAIN promoter in peripheral blood of individuals with ASD (red color), compared to controls (green color). BEGAIN was hypomethylated in autistic samples in all three age groups, consisting of 20 matched pairs ≤ 10 years, 18 pairs between 11 and 19 years, and 8 pairs ≥ 20 years, respectively. In the two younger groups the between-group difference was significant. The median is presented by a horizontal line. The bottom of the box indicates the 25th and the top the 75th percentile.