Research Paper Volume 15, Issue 23 pp 13888—13900
HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2
Figure 9. The activation of NRF2 reduced the effects of si-HACE1 in model of heart failure. NRF2 and GPX4 protein expression (A, B), MDA/ROS/SOD/GSH/GSH-PX levels (C–G), cell viability (H), LDH activity (I), IL-1α level (J), Iron concentration levels (K), JC-1 disaggregation (L). NRF2 and GPX4 protein expression in blot and immunofluorescence (M, N). ##p<0.01 compared with si-nc group, **p<0.01 compared with si-HACE1 group.