Research Paper Volume 15, Issue 23 pp 13888—13900
HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2
Figure 3. The inhibition of HACE1 promoted oxidative stress in vitro model. HACE1 mRNA expression (A), MDA, ROS, SOD, GSH and GSH-px levels (B–F), collagen I, collagen III and TGF-β mRNA expression (G–I). ##p<0.01 compared with si-nc group. Immunofluorescence images of si-HACE1 activity (J).