HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

Peiyi Yin; Yongbin Wu; Xiang Long; Shuqiang Zhu; Shiwei Chen; Feng Lu; Kun Lin; Jianjun Xu

doi:doi:10.18632/aging.205272

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Research Paper Volume 15, Issue 23 pp 13888—13900

HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

Figure 1. The expression levels of HACE1 in patients with heart failure. HACE1 mRNA expression (A), HACE1 related to collagen I or collagen III (B, C), ROC curve (D) in patients with Heart failure; HACE1 mRNA and promoted expression-rtPCR (E, F) and wester blot (G) in mice model of Heart failure. ##p<0.01 compared with normal group or sham group.