Research Paper Volume 15, Issue 23 pp 13854—13864
Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats
Figure 7. MEG8 overexpression reversed the Th17/Treg ratio imbalance by upregulating STAT3 within HSP CD4+ T cellular populations. (A) STAT3 mRNA level, (B) STAT3 protein level, (C–E) analysis of Th17 and Treg cells, and (F) the Th17/Treg cell ratio in HSP CD4+ T cells simultaneously transfected with the empty vector/MEG8 overexpression vector and scrambled siRNA/si-STAT3. *P <0.01 vs. Vector + scramble group; #P <0.01 vs. MEG8 + scramble group.