BDH1-mediated βOHB metabolism ameliorates diabetic kidney disease by activation of NRF2-mediated antioxidative pathway

Sheng-Rong Wan; Fang-Yuan Teng; Wei Fan; Bu-Tuo Xu; Xin-Yue Li; Xiao-Zhen Tan; Man Guo; Chen-Lin Gao; Chun-Xiang Zhang; Zong-Zhe Jiang; Yong Xu

doi:doi:10.18632/aging.205248

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Research Paper Volume 15, Issue 22 pp 13384—13410

BDH1-mediated βOHB metabolism ameliorates diabetic kidney disease by activation of NRF2-mediated antioxidative pathway

Figure 9. Schematic diagram depicting the mechanism by which BDH1-mediated βOHB metabolism ameliorates DKD. Abbreviations: BDH1: β-hydroxybutyrate dehydrogenase 1; βOHB: β-hydroxybutyrate; DKD: diabetic kidney disease.