Research Paper Volume 15, Issue 22 pp 13176—13193
Investigating EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy: an in silico and in vitro validation study
Figure 4. Expression profile of necroptosis-related gene markers in the bulk RNA-seq data (GSE96804) and validation in the test cohort (GSE142025). (A) Violin plot showing the expression levels of genes related to necroptosis in the bulk RNA-seq data. (B) Receiver operating characteristic curves of EGF, PAG1 and ZFP36 in the bulk RNA-seq data. (C) The expression levels of necroptosis-related biomarkers as validated by the external independent dataset and shown as a violin plot. (D) The performance of EGF, PAG1 and ZFP36 in the external independent dataset as determined by receiver operating characteristic curves. (**p<0.01; ***p<0.001, compared DN and control group).