Research Paper Volume 15, Issue 15 pp 7760—7780

Figure 3. Identification of hub genes and evaluation of correlation with immune infiltration of hub genes. (A) Scatter plot of the genes in the greenyellow module. Each green dot represents a gene, and dots within the red box indicate genes of Module Membership >0.7 and Gene Significance >0.2. (B) PPI network of genes from the greenyellow module. Larger size of the node means higher number of connected nodes. Green nodes represent central nodes with more than 15 connections. (C) Venn plot of the overlap genes between co-expression and PPI networks. (D) Scatter plot of the correlation between 11 hub genes expression and CD8+ T cell infiltration level in TIMER database. (E) Scatter plot of the correlation between MYEF2 expression and CD8+ T cell infiltration level in TIMER database. (F) Heatmaps of spearman correlations between hub genes expression and expression of immune-inhibitory factors in TISIDB database. (G) PPI network of GBM immune microenvironment and the 11 hub genes.