Research Paper Volume 15, Issue 15 pp 7709—7726
Inhibition of BACE1 attenuates microglia-induced neuroinflammation after intracerebral hemorrhage by suppressing STAT3 activation
Figure 2. MK-8931 attenuated ICH induced neurological deficits via BACE1 inhibition. (A, B) ICH was induced in mice by injection of autologous blood. Summarized results showing neurological assessment (mNSS score, corner-turning test) of the MK-8931- or vehicle-treated groups of mice. n = 8 per group. (C) Brain water content in groups of mice receiving the indicated treatments at Day 1 after ICH. n = 11 per group. (D) Representative coronal sections showing hematomas from the indicated treated mice. (E–G) Quantification of residual hemoglobin, hematoma volume, and hematoma index (volume × density). n = 8 per group. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01.