Research Paper Volume 15, Issue 14 pp 7023—7037
Single-cell transcriptomics reveals the drivers and therapeutic targets of lymph node metastasis in lung adenocarcinoma
Figure 1. Clustering of cells in tumor and lymph node samples from early and advanced stage LUAD patients. (A) Overview of the scRNA-seq and bulk RNA-seq cohorts. (B) T-SNE visualization of 24 cell clusters from scRNA-seq cohort samples, and (C) showing various origin of the cells. (D) Eight cell clusters were manually annotated based on DEGs according to canonical cell lineage markers. (E) Comparison of the cell constitution among different tissues shown by the bar plot. Abbreviations: LUAD: lung adenocarcinoma; esPT: primary tumor in early stage LUAD; esLN: lymph node in early stage LUAD; asPT: primary tumor in advanced stage LUAD; asLN: lymph node in advanced stage LUAD; LNM: lymph node metastasis.