Research Paper Volume 15, Issue 14 pp 6950—6968

Single-cell sequencing analysis reveals the relationship between tumor microenvironment cells and oxidative stress in breast cancer bone metastases

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Figure 5. Clonal evolution of fibroblast subpopulations in patients with bone metastases from breast cancer. (A, B) Pseudo-time values (A) and developmental trajectories (B) of fibroblast subpopulations, with pie charts representing the proportion of fibroblast subpopulations in control and breast cancer bone metastasis patients. (C) Co-expression modules of transcription factors in fibroblast subpopulations of patients with breast cancer bone metastases. Left: Identification of regulator modules based on the regulators linkage specificity index matrix. Middle: representative transcription factors and their binding patterns in the modules. Right panel: cell subpopulations in which transcription factors are located. (D) Single-cell atlas showing transcription factors regulating fibroblast subpopulations.