Research Paper Volume 15, Issue 15 pp 7408—7423
Senescence-related gene c-Myc affects bladder cancer cell senescence by interacting with HSP90B1 to regulate cisplatin sensitivity
Figure 1. Prognostic key genes of senescence associated with cisplatin IC50 in bladder cancer. Volcano plot (A) and heat map (B) show the differential analysis of bladder cancer samples and normal bladder samples in The Cancer Genome Atlas (TCGA) database. (C) intersection of differential genes and senescence-associated genes in bladder cancer samples. (D) univariate analysis of senescence-associated differential genes and cisplatin IC50 score analysis. (E) univariate analysis results of 11 senescence genes were plotted using forest plots. (F) Correlations of 11 senescence genes were demonstrated using chord diagrams. (G) In bladder cancer, 11 senescence genes were analyzed in high and low expression groupings identify the differences between them and to compare cisplatin IC50 scores.