Research Paper Volume 15, Issue 13 pp 6031—6072

Figure 1. Experimental outline and age comparison. (A) Time-course of housing provision and experimental treatments for Adult mice (upper panel) and Aged mice (lower panel). Abbreviations: P: postnatal day; MWM: Morris water maze; LTP: long-term potentiation and electrophysiological analysis of synaptic transmission. (B) Comparison of mouse and human ages based on data from Wang et al., (2020) [71]. The broken vertical lines represent the weeks at which two separate cohorts of mice (blue; Adult and red; Aged): went into enrichment (weeks 26 and 78); behavioural testing started (weeks 36 and 88), behavioural testing ended (weeks 42 and 92), and the end of ex vivo analyses (weeks 50 and 100). For comparison, the previously reported young group (cyan) were born into standard housing or enrichment (week 0), began behavioural testing at week 10, with all testing completed by week 20 [36].