Research Paper Volume 8, Issue 10 pp 2488—2508
Dissociation between iron accumulation and ferritin upregulation in the aged substantia nigra: attenuation by dietary restriction
Figure 10. (A) Dietary restriction reduces age-related increases in Iba1 in DR compared to AL mice. Solid black line indicates the outcome of two-way ANOVA testing; **** P < 0.0001 for effect of age; # P < 0.05 for an effect of treatment; α, P < 0.05 for an age-feeding regimen interaction. Dotted line indicates post-hoc testing at the significance levels ** P < 0.01 and *** P < 0.001.] Micrographs showing higher numbers of Iba1-positive cells in (B) AL compared to (C) DR mice at 19 months. Black arrows point to Iba1-immunopositive cells.