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Research Paper Volume 8, Issue 10 pp 2449—2462

Inducing cellular senescence in vitro by using genetically encoded photosensitizers

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Figure 1. Overview of the method used to optogenetically induce cellular senescence in vitro. (A) Model illustrating how mild genotoxic stress can induce cellular senescence-like proliferation arrest (according to [30]). (B) Overview of the method for inducing cellular senescence using the genetically encoded photosensitizers tandem KillerRed (tKR) and miniSOG that were targeted to chromatin.