RESEARCH PERSPECTIVE

AGING, Vol 2, No 8 , pp 514-518
PDF version     |     Full text

P66SHC and Ageing: ROS and TOR?

Giovambattista Pani
Institute of General Pathology, Universita' Cattolica Medical School, Rome Italy
Key words:
p66shc, mTOR/S6K, ageing, calorie restriction, nutrient-sensing, diabetes
Received:
07/24/10; accepted: 07/27/10; published on line: 07/28/10
Corresponding author:
E-mail:

Abstract

Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or TOR?" dilemma.