Exploring the effect and mechanism of Aloin A against cancer cachexia-induced muscle atrophy via network pharmacology, molecular docking, molecular dynamics and experimental validation

Awaguli Dawuti; Lisha Ma; Xueyan An; Jiawei Guan; Changdong Zhou; Linyun He; Yue Xu; Bo Han; Abudumijiti Abulizi

doi:doi:10.18632/aging.205416

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Research Paper Volume 15, Issue 24 pp 15557—15577

Exploring the effect and mechanism of Aloin A against cancer cachexia-induced muscle atrophy via network pharmacology, molecular docking, molecular dynamics and experimental validation

Figure 5. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. (A) KEGG enrichment analysis. The Y-axis represents KEGG pathways. The X-axis indicates the enrichment p-value. (B) Drug-Pathway-Target construction. The red represents drug. The yellow represents related pathway. The blue represents related target genes.